Home runs from power hitters are among the biggest draws in baseball. Wednesday’s MLB schedule features several such sluggers with favorable matchups. As such, the home run prop bets market offers intriguing value.
Let’s take a look at the best home run prop bets to watch for Wednesday’s game.
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Today’s Best MLB Home Run Prop Bets
5.James Wood (+480) (Nationals vs Guardians)
James Wood is arguably the loudest pick on this slate right now. He has already hit homers in his last two games against the Cleveland Guardians on Monday and Tuesday.
Wood’s physical profile is scary for opposing pitchers. He routinely registers exit velocities north of 114 mph. Moreover, he leads MLB this season in opposite-field homer runs.
Pitcher can’t try to bust him inside or fade him away. His massive coverage allows him to drive mistakes over any fence to record his 16th home run of 2026.
4.Mitch Garver (+324) (Mariners vs Athletics)
Mitch Garver’s value lies in his pull-side power and high flyball-to-linedrive ratio. His profile maps well against the Athletics’ pitching staff, who are prone to leaving breaking stuff hanging in the top half of the zone.
Garver is structurally built to punish those types of pitching mistakes. Therefore, he will likely record his third homer of 2026 on Wednesday.
3.George Springer (+313) (Mariners vs Blue Jays)
George Springer excels at hard contact right out of the gate as the leadoff hitter. He is coming off a three-hit performance against the Marlins on Tuesday.
Miami’s pitching staff relies on high four-seam fastballs, intended to force weak pop-ups. Springer is adept at punishing velocity up in the zone. As such, the chances of him recording his sixth homer of 2026 on Wednesday are high.
2.Kyle Schwarber (+260) (Phillies vs Padres)
Kyle Schwarber is a streak hitter. Moreover, he’s lethal when locked in. He was the first in 2026 to reach 20 homers. His barrel rates and raw power are dialled in.
A locked-in Schwarber will likely jump on an aggressive fastball early in the count from the Padres pitching staff. Right-handed bats sometimes struggle at Petco Park, but Schwarber’s elite lefty pull-side launch angle translates across any ballpark.
1.Randy Arozarena (+244) (Mariners vs Athletics)
Randy Arozarena carries a strong record against the Athletics. He enters Wednesday’s matchup with a .297 average and .856 OPS.
Arozarena was quite against the Athletics on Tuesday, striking out twice in five at-bats. He was impressive against their divisional rivals on Monday, recording three hits, of which one was a homer.
Arozarena’s modified swing has minimized chasing out of the zone. He will be a huge threat against the Athletics pitchers, who rely on multi-seam fastballs. Seventh home run of 2026 for him is on the horizon on Wednesday.
(Source: DraftKings Sportsbook)
(NB: Odds subject to change)
Edited by Safeer M S