Emma Hayes’ side are targeting a third successive title and fifth overall having dispatched an Arsenal side including Kerr’s Matildas teammates Caitlin Foord and Steph Catley 2-0 in the previous round.
Kerr – freshly returned from Australia’s Cup of Nations triumph on home soil – scored in that clash, taking her overall tally for the English champions to an astonishing 82 goals in 100 games.
Lewes, the lowest-ranked team left in the competition, host Women’s Super League leaders Manchester United in what will be their first appearance in the quarter-finals.
Alongside Lewes, Birmingham City are the second Women’s Championship side still left in the tournament and they face Lydia Williams’ Brighton at home.
Completing the draw, Manchester City’s Matildas trio of Alanna Kennedy, Mary Fowler and Hayley Raso will visit Emily Gielnik’s Aston Villa.
Women’s FA Cup quarter-finals to be played on Sunday, March 19:
Reading v Chelsea
Aston Villa v Manchester City
Lewes v Manchester United
Birmingham City v Brighton.