The pressure was already on Real Madrid coach Xabi Alonso and a 2-1 defeat to Manchester City in the Champions League on Wednesday raised further questions about his future.
It’s now just two wins in eight games for Madrid and back-to-back home losses after goals from Nico O’Reilly and Erling Haaland sealed victory for City.
Elsewhere, Arsenal remains perfect in the Champions League after a 3-0 win against Club Brugge continued its 100% record.
Defending champion Paris Saint-Germain was held 0-0 at Athletic Bilbao.
Ajax scored three goals late in the game to deny Qarabag a surprise win in one of the early kickoffs.
Four-time European champion Ajax twice trailed against its Azerbaijani opponent, but fought back to win 4-2 in Baku.
Qarabag has been one of the surprise packages in this season’s competition and led after 10 minutes through Camilo Duran. Matheus Silva scored two minutes into the second half to make it 2-1 after Kasper Dolberg had leveled for Ajax.
But Ajax powered back with three goals in 11 minutes. Oscar Gloukh scored in the 79th and 90th, with Anton Gaaei getting the other in the 82nd.
Copenhagen also scored late to win 3-2 at Villarreal
Substitute Andreas Cornelius struck in the 90th to seal victory in a game where Copenhagen had twice been pegged back after taking the lead.