The San Diego Padres host the San Francisco Giants at Petco Park on Monday, beginning their second series of the MLB regular season.
In their first series, the Padres were beaten 2-1 by the Detroit Tigers, while the Giants were disappointingly swept by the Yankees at home.
Let’s take a look at the odds, preview, prediction and best betting tips for this fixture.
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MLB: San Diego Padres vs San Francisco Giants Odds
Money Line: San Diego Padres (-118), San Francisco Giants (-102)
Run Line: San Diego Padres -1.5 (+162), San Francisco Giants +1.5 (-215)
Total Runs: Over 8.5 (-101), Under 8.5 (-119)
Preview – Probable starting pitchers and lineups
San Diego Padres probable starting pitcher: Walker Buehler
Walker Buehler gets the nod to start this game for the Padres. Having made his MLB debut in 2017, Buehler has enjoyed plenty of success at the top level, earning two All-Star selections and winning the World Series twice.
In 2025, however, he endured a tough season, finishing with a 10-7 record, a 4.96 ERA and 92 strikeouts.
San Diego Padres predicted lineup:
- OF Fernando Tatis Jr.
- SS Xander Bogaerts
- 3B Manny Machado
- OF Jackson Merrill
- DH Miguel Andujar
- 1B Gavin Sheets
- OF Ramon Laureano
- C Freddy Fermin
- 2B Jake Cronenworth
San Francisco Giants probable starting pitcher: Landen Roupp
Landen Roupp takes the mound for the Giants. Making his first MLB appearance in 2024, Roupp is much less experienced than his opposite number. However, he was much better last season, finishing with a 7-7 record, a 3.80 ERA and 102 strikeouts.
San Francisco Giants predicted lineup:
- 2B Luis Arraez
- 3B Matt Chapman
- DH Rafael Devers
- SS Willy Adames
- OF Jung Hoo Lee
- OF Heliot Ramos
- 1B Casey Scmitt
- C Patrick Bailey
- OF Harrison Bader
The Giants come into this game in desperate need of a win, but the Padres are playing at home and in slightly better form, making them favorites to win this.
Prediction: San Diego Padres 6, San Francisco Giants 3
Betting Tips
Cheered on by Petco Park, the Padres should be able to secure an important win, taking their MLB record to .500 in the process.
Money Line: San Diego Padres (-118)
Run Line: San Diego Padres -1.5 (+162)
Total Runs: Over 8.5 (-101)
Likely players to hit home runs: Fernando Tatis Jr. (San Diego Padres), Jackson Merrill (San Diego Padres), Rafael Devers (San Francisco Giants), Willy Adames (San Francisco Giants)
Edited by Raghav Mehta