The Minnesota Twins host the Detroit Tigers at Target Field on Wednsday, continuing their fourth series of the 2026 MLB season.
The Twins have dominated proceedings so far, winning both games one and two, while outscoring the Tigers 11-5.
Let’s look at the odds, preview, prediction and best betting tips for this game.
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MLB: Minnesota Twins vs Detroit Tigers Odds
Money Line: Minnesota Twins (+129), Detroit Tigers (-156)
Run Line: Minnesota Twins +1.5 (-131), Detroit Tigers -1.5 (+109)
Total Runs: Over 8 (-112), Under 8 (-108)
Preview – Probable starting pitchers and lineups
Minnesota Twins probable starting pitcher: Bailey Ober
Bailey Ober gets the nod to start this game for the hosts. Having made his MLB debut in 2021, Ober has established himself as an important member of the Twins’ starting rotation.
The righty has not enjoyed the best of starts to the year, coming into this game with a 6.75 ERA for his first two outings.

Minnesota Twins predicted lineup:
- OF Byron Buxton
- OF Austin Martin
- 2B Luke Keaschall
- C Ryan Jeffers
- 1B Victor Caratini
- DH Josh Bell
- OF Matt Wallner
- 3B Royce Lewis
- SS Brooks Lee
Detroit Tigers probable starting pitcher: Framber Valdez
Framber Valdez takes the mound for the visitors. Signing a three-year, $115 million contract to join the Tigers over the winter, the southpaw has lived up to the hype so far, giving up only a single earned run over two starts so far.

Detroit Tigers predicted lineup:
- DH Colt Keith
- 3B Kevin McGonigle
- 2B Gleyber Torres
- OF Riley Greene
- C Dillon Dingler
- OF Zach McKinstry
- 1B Spencer Torkelson
- OF Parker Meadows
- SS Javier Baez
The Twins will enter this game full of confidence after handing Tarik Skubal a loss on Tuesday. However, the Tigers should have enough quality to correct course with another dominant lefty on the mound.
Prediction: Minnesota Twins 3, Detroit Tigers 6
Betting Tips
Framber Valdez should be able to guide the Tigers to an important win on Wednesday, allowing them to stay alive in the series.
Money Line: Detroit Tigers (-156)
Run Line: Detroit Tigers -1.5 (+109)
Total Runs: Over 8 (-112)
Likely players to hit home runs: Byron Buxton (Minnesota Twins), Royce Lewis (Minnesota Twins), Riley Greene (Detroit Tigers), Gleyber Torres(Detroit Tigers)
Edited by Raghav Mehta