The San Diego Padres host the St. Louis Cardinals at Petco Park on Sunday, concluding their 13th series of the 2026 MLB season. The Cardinals won the first two games of the series, before the Padres responded with a victory of their own on Saturday.
Let’s look at the odds, preview, prediction and best betting tips for the game.
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MLB: San Diego Padres vs St. Louis Cardinals odds
Money Line: San Diego Padres (-131), St. Louis Cardinals (+109)
Run Line: San Diego Padres -1.5 (+159), St. Louis Cardinals +1.5 (-194)
Total Runs: Over 8 (-115), Under 8 (-105)
Preview – Probable starting pitchers and lineups
San Diego Padres probable starting pitcher: Walker Buehler
Walker Buehler gets the starting nod for the hosts. The veteran comes into the game with a 2-2 record and a 5.64 ERA.
San Diego Padres predicted lineup:
- OF Ramon Laureano
- OF Fernando Tatis Jr.
- OF Jackson Merrill
- 3B Manny Machado
- SS Xander Bogaerts
- DH Nick Castellanos
- 1B Ty France
- C Freddy Fermin
- 2B Jake Cronenworth
St. Louis Cardinals probable starting pitcher: Kyle Leahy
Kyle Leahy takes the mound for the visitors. The righty comes into the matchup with a 4-3 record and a 4.93 ERA.
St. Louis Cardinals predicted lineup:
- 2B JJ Wetherholt
- DH Ivan Herrera
- 1B Alec Burleson
- OF Jordan Walker
- 3B Nolan Gorman
- SS Masyn Winn
- OF Nathan Church
- C Pedro Pages
- OF Victor Scott II
The Cardinals’ offense has shown they can cause the Padres problems. However, the Friars will be desperate to secure another win on Sunday, with a chance to split the four-game series.
Prediction: San Diego Padres 4, St. Louis Cardinals 4
Betting Tips
The Padres are strong at home, and they should have enough in the tank to secure a hard-fought win on Sunday.
Money Line: San Diego Padres (-131)
Run Line: St. Louis Cardinals +1.5 (-194)
Total Runs: Over 8 (-115)
Likely players to hit home runs: Fernando Tatis Jr. (San Diego Padres), Jackson Merrill (San Diego Padres), JJ Wetherholt (St. Louis Cardinals), Jordan Walker (St. Louis Cardinals)
Edited by Raghav Mehta